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The gene showed a specific immune response to the enzyme HRP after its insertion in an Escherichia coli plasmid. High blood pressure is the most common modifiable risk factor for cardiovascular morbidity and mortality. Successful oral rehabilitation requires precise fixed prostheses that are.

In this study, biodiesel was produced from waste cooking oil using two catalysts including KOH and NaOH. For this purpose, the effect. GET STARTED NOW View more SCHOLARENAScholarena, an open access publisher dedicated to the scientific community.

HOME ABOUT SUBMIT MANUSCRIPT CONTACT Open Access by Scholarena is licensed under a Creative Commons Attribution 4. A short overview of performed and ongoing research projects within forensic toxicology is listed below:The most common ante- and postmortem collected specimens for analyzes include blood, urine, saliva but also gastric contents, vitreous humor and bile.

However, in forensic cases these specimens are often degraded or not available at all due to decomposition. In cases of extreme putrefaction, most of the time only bone, hair and nails remain. These specimens are foremost the best protected from decomposition and are proven to be a depot for certain drugs. This raises the opportunity of drug detection over a larger time frame as well as the documentation of the history of usage over time.

These less traditional matrices are subject of this research. The results will be compared with results found in more traditional matrices where possible. In forensic toxicology, trace analysis of drugs in complex biological samples is daily routine. Despite the available state-of-the-art analytical instruments, sample preparation is still a crucial step in order to detect and quantify trace amounts of drugs.

To date, various sample preparation techniques have been developed, however, it still remains a challenge to efficiently extract a wide range of compounds with varying physicochemical properties.

This is even more challenging when analyzing complex matrices such as (postmortem) whole blood samples. In this respect, ionic liquids seem to offer new perspectives as alternative extraction solvents; replacing the commonly used volatile organic solvents. Their popularity can be attributed to the pronounced physicochemical properties such as good thermal and chemical stability, high electrical conductivity and their non-flammable nature.

In collaboration with prof. Dehaen and coworkers (Molecular Design and Synthesis, Chemistry Department, KU Leuven), new ionic liquids will be designed for the specific extraction of these broad groups of drugs, such as benzodiazepines, from complex matrices.

Our goal is to obtain ionic liquids that are able to extract with high efficiency and develop an optimized liquid-liquid microextraction protocol. Differentiation between human and animal remains by means of analysis of volatile compounds released during decomposition is impossible since no volatile marker(s) specific for human decomposition has been established today. This project aims to identify odor compounds that are involved in decomposition of human and animal remains and further identify one or more specific markers in the human decomposition (qualitatively or quantitatively).

A breakthrough can lead to significant progress in several forensic domains: a more specific training for cadaver dogs, a better understanding of forensic entomology, and a more specific and sensitive detection and identification of human remains using analytical techniques. Narcotic analgesics are widely used for the treatment of moderate to severe pain, making them important in the clinical world.

These drugs can be lowly dosed in biological samples, making (ab)use of these compounds hard to detect. Sensitive and accurate detection of narcotic analgesics and metabolites is thus clearly required for both clinical and forensic investigations. In this study, several factors (sample preparation, ionization interface, mobile phase and column) were optimized in order to maximize efficiency and sensitivity.

After optimization, the method was fully validated in both urine and whole blood. As a result nine narcotic analgesics and metabolites (buprenorphine, O-desmethyltramadol, fentanyl (spectrum below), norbuprenorphine, norfentanyl, pethidine, piritramide, tilidine and tramadol) can be detected in biological matrices with superior sensitivity. Navigatie Staff Members Publications Instrumentarium How to reach us.

With a broad repertoire of analytical techniques and experienced staff, we are able to support a wide range of customer led research and development projects. These typically complement our own work which helps increase the body of toxicological knowledge for the broader scientific community both nationally and internationally.

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